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There is a lot of contradictory information out there regarding the benefits and detriments of juicing. You can see some "rules" about which juices to avoid, or possibly dangerous combinations of juicing ingredients. Let's take a look at some of these and see if they hold up.
A new trend among some people these days is called Mono Eating. Advocates of this state that our bodies are designed to only consume one ingredient at a time. This is a myth. To say that you can't combine fruit with meat, or fruit with grains, or especially fruits with vegtables is just not true.
The fact is that our digestive system is designed to handle a wide variety of food. Whether or not they are eaten separately or together doesn't matter. There is no truth that combining fruits with vegetables causes food to accumulate and decay in the intestines, disrupt pH levels, or destroy vital enzymes that are necessary for digestion.
Since it's true that fruits generally contain a lot of sugar, does that mean we should limit their consumption? In the case of eating whole fruit, it's not a problem since at the same time you are consuming the insoluble fiber which slows the absorption rate of the sugar. The benefit of juicing is the high absorption rate of vitamins - up to 4 times more vitamins are taken in by the body through juice versus eating whole fruit. The downside of juicing pure fruit juice is that there is no fiber to slow the absorption rate of sugars into the bloodstream.
So with pure fruit juice, we need to be careful, especially adults. For example, it wouldn't be a good idea to drink a large quantity of 100% grape juice. It would cause a rapid spike in blood sugar levels, followed by a corresponding crash and would put a lot of stress on the pancreas.